Research Articles
Optimizing NGS Variant Calling Pipelines: A Comprehensive Guide from Foundational Concepts to Clinical Validation
This article provides researchers, scientists, and drug development professionals with a comprehensive framework for next-generation sequencing (NGS) variant calling pipelines.
Beyond the Genome: Integrating NGS with Multi-Omics to Power Next-Generation Precision Oncology
The molecular complexity of cancer demands a systems-level approach that moves beyond single-omics analyses.
Next-Generation Sequencing for Minimal Residual Disease Monitoring: A Transformative Tool for Precision Oncology and Drug Development
Next-generation sequencing (NGS) has revolutionized minimal residual disease (MRD) monitoring in hematologic malignancies, offering unprecedented sensitivity down to 10^-6 and the unique ability to track clonal evolution.
Mastering FFPE Sample Preparation for Robust NGS Library Construction: A Comprehensive Guide for Researchers
Next-generation sequencing (NGS) of Formalin-Fixed Paraffin-Embedded (FFPE) samples unlocks vast potential for cancer research and clinical diagnostics, yet the path to high-quality data is fraught with technical challenges.
RNA Sequencing for Gene Fusion Detection in Cancer: A Comprehensive Guide for Researchers and Drug Developers
This article provides a comprehensive overview of RNA sequencing (RNA-seq) for detecting clinically relevant gene fusions in cancer.
From Code to Cure: Integrating DNA and RNA Sequencing in Modern Oncology
This article provides a comprehensive overview of the principles and clinical applications of Next-Generation Sequencing (NGS) in oncology, covering both DNA and RNA sequencing.
Decoding Cancer Complexity: How Next-Generation Sequencing Unravels Tumor Heterogeneity for Precision Oncology
Next-generation sequencing (NGS) has fundamentally transformed our understanding and investigation of cancer heterogeneity, moving beyond organ-based classification to a molecular-level understanding of tumor evolution, resistance, and metastasis.
Tumor Mutational Burden Measurement by NGS: A Comprehensive Guide for Cancer Researchers and Drug Developers
This article provides a comprehensive examination of Tumor Mutational Burden (TMB) as a predictive biomarker for immunotherapy response, focusing on Next-Generation Sequencing (NGS) methodologies.
Next-Generation Sequencing in Immuno-Oncology: Unlocking Biomarker Discovery for Precision Cancer Therapies
This article provides a comprehensive overview of how Next-Generation Sequencing (NGS) is revolutionizing biomarker discovery in immuno-oncology.
Liquid Biopsy and Circulating Tumor DNA: A Revolutionary Tool for Cancer Detection and Monitoring
This article provides a comprehensive overview of the transformative role of liquid biopsy and circulating tumor DNA (ctDNA) analysis in modern oncology.