Research Articles
ctDNA Tumor Fraction in Early-Stage Cancer: A Research and Clinical Development Guide
This article provides a comprehensive analysis of circulating tumor DNA (ctDNA) fraction, a critical biomarker in early-stage cancer.
Structure-Based vs. Ligand-Based Pharmacophore Modeling: A Comprehensive Guide for Effective Drug Discovery
This article provides a comparative analysis of structure-based and ligand-based pharmacophore modeling, two pivotal computational strategies in modern drug discovery.
Strategic Training Set Selection in Ligand-Based Pharmacophore Modeling: A Guide for Robust Virtual Screening and Hit Identification
Ligand-based pharmacophore modeling is a cornerstone of computer-aided drug design, particularly for targets with unknown 3D structures.
Pharmacophore vs. Docking-Based Virtual Screening: A Performance Comparison for Drug Discovery
This article provides a comprehensive comparison of pharmacophore-based virtual screening (PBVS) and docking-based virtual screening (DBVS) for researchers and drug development professionals.
Advanced Strategies for Pharmacophore Feature Selection and Weight Optimization in Modern Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on optimizing pharmacophore feature selection and weighting, a critical step for enhancing virtual screening success and designing selective...
Validating Pharmacophore Models with Decoy Sets: A Comprehensive Guide for Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on the critical process of validating pharmacophore models using decoy sets.
Building a Modern High-Throughput Pharmacophore Screening Pipeline: From AI-Driven Foundations to Clinical Hit Validation
This article provides a comprehensive guide for researchers and drug development professionals on constructing and implementing a high-throughput pharmacophore virtual screening pipeline.
Ligand-Based Pharmacophore Modeling with LigandScout: A Comprehensive Workflow for Drug Discovery
This article provides a comprehensive guide to ligand-based pharmacophore modeling using LigandScout, tailored for researchers and drug development professionals.
Pharmacophore-Based Virtual Screening: A Comprehensive Workflow Guide for Modern Drug Discovery
This article provides a comprehensive introduction to pharmacophore-based virtual screening (PBVS), a powerful computational method that significantly accelerates drug discovery by identifying potential therapeutic candidates from large chemical databases.
Pharmacophore Modeling in Modern Drug Discovery: A Comprehensive Guide to Methods, Applications, and AI-Driven Advances
This article provides a comprehensive examination of pharmacophore modeling's pivotal role in computer-aided drug design, addressing the needs of researchers and drug development professionals.