Research Articles
PHT-427: A New Frontier in Cancer Therapy Targeting Cellular Signaling Hubs
Explore the molecular pharmacology and antitumor activity of PHT-427, a novel dual-targeting inhibitor of Akt and PDPK1 with promising cancer therapeutic potential.
Double Trouble: How Simultaneously Targeting Two Cellular Proteins Could Revolutionize Cancer Therapy
Explore how dual targeting of HDAC6 and Hsp90 proteins creates a powerful approach to combat treatment-resistant cancers through synergistic mechanisms.
The Double-Edged Sword of Epigenetics: How a Promising Drug Reveals a Surprising Dark Side
Discover how the cancer drug 5-aza-2'-deoxycytidine's toxicity comes from DNA methyltransferase trapping rather than DNA demethylation, reshaping epigenetic therapy approaches.
The Tumor-Targeting Revolution: How Liquid Metal Nanoprobes are Transforming Cancer Therapy
Explore how bioorthogonal glycoengineering-mediated liquid metal nanoprobes are revolutionizing cancer therapy through precise targeting and multifunctional treatment approaches.
Unlocking a Cancer Pill: How Glycocholic Acid Micelles Revolutionize Chemotherapy Delivery
Explore how glycocholic acid-modified micelles enable oral delivery of gemcitabine for cancer therapy, overcoming bioavailability challenges through nanotechnology.
Smart Nanobullets: How pH-Sensitive Particles Are Revolutionizing Cancer Therapy
Explore how pH-sensitive nanoparticles are transforming cancer therapy by delivering drugs precisely to tumors while minimizing side effects.
Pillararenes: The Next Generation of Smart Cancer Therapy
Exploring pillararene-based supramolecular delivery systems for targeted cancer therapy with reduced side effects
Dialkynylimidazoles: The Revolutionary Two-Pronged Weapon in the Fight Against Cancer
Discover how dialkynylimidazoles are redefining targeted cancer therapy through irreversible MAPK inhibition and molecular probing.
Light-Activated Nanomaterials: A Precise New Weapon Against Cancer
Explore how light-activated nanomaterials are revolutionizing cancer treatment through precise targeting and reduced side effects.
How a Bacterial Enzyme Became a Life-Saving Cancer Drug
Discover how Escherichia coli L-asparaginase evolved from a bacterial enzyme to an essential cancer therapy for acute lymphoblastic leukemia through structural biology insights.